The Chicago Cubs (60-42) visit the South Side of Chicago to face the Chicago White Sox (37-66) Friday in the first game of a 3-game interleague series. First pitch from Rate Field is at 7:40 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

SportsLine's proven model has simulated the Chicago White Sox vs. Chicago Cubs 10,000 times and released its MLB best bets for Illinois sportsbooks

Cubs rookie Cade Horton has been inconsistent, but he has fanned 4+ batters in five of his last seven starts. He'll face a White Sox lineup that is 29th in the majors in OPS (.660) and 24th in strikeout rate (23.2%).