Preview the Week 13 matchup between the San Francisco 49ers and Cleveland Browns with predictions, odds, over/under, spread, betting lines and more.

Shedeur Sanders is celebrating his first NFL start with a new merchandise drop. Deion Sanders Jr. revealed a first look at new merch from his brother's "2Legendary" brand at the 4:35 mark of a video shared Saturday by Well Off Media. Sanders, 23, joined the Browns as a fifth-round pick out of Colorado.

QB  Baker Mayfield  (left shoulder) is expected to play Sunday against the Cardinals, NFL Network Insider Ian Rapoport reported. RB  Bucky Irving  (shoulder/foot), who has not played since Week 4, is expected to play Sunday, Rapoport reported. LB  Haason Reddick  (ankle/knee) is expected to play Sunday, Rapoport reported.

The NFL hands down a punishment for San Francisco 49ers WR Jauan Jennings after his postgame brawl with Panthers' Tre'von Moehrig.

Rookie Shedeur Sanders reportedly has a chance to remain the Cleveland Browns' starting quarterback for the rest of the 2025 season.

Facing a 3-8 Cleveland Browns team is superficially an easy matchup for the San Francisco 49ers. However, the Browns have one of the best defenses in the NFL. N

As the Cleveland Browns get set to take on the San Francisco 49ers at home on Sunday, they have requested some help from their practice squad. They have elevated defensive lineman Sam Kamara from the practice squad for tomorrow's matchup.