Traveling after Thanksgiving may be a bit more turbulent than before, as a cross-country storm will bring snow to millions.

Thanksgiving Day is here at last, and for tens of millions of folks in the eastern half of the country, brisk, cold winds will be the main weather story.

More than 2,200 flights traveling to, from or within the U.S. were delayed as of Friday afternoon, according to flight tracking website FlightAware, with 50 flights canceled.

A winter storm watch is in place for North Dakota and Minnesota, where 3 to 9 inches of snow may fall from Monday night through Wednesday morning. Wind gusts may reach 40 mph, causing blowing and drifting snow. More than 6 inches of snow is possible and wind gusts up to 45 mph could lead to whiteout conditions.

For the holiday, lake-effect snow is likely to develop downwind of the Great Lakes. “Those traveling on Thanksgiving Day around the Great Lakes region may have to contend with typical lake-effect snow showers, which can result in reduced visibility and slippery travel,” Duff said.

The biggest lake-effect snow event of the season thus far is pummeling the Great Lakes Snowbelt, and is expected to deliver feet of snow through Black Friday, creating long periods of life-threatening travel conditions across major Interstate highways this Thanksgiving holiday.

A Thanksgiving snowstorm could dump as much as 3 feet across parts of the Great Lakes region, with AccuWeather meteorologists warning that "some highways may close" ahead of a busy travel day as Americans celebrate Thanksgiving.

Heavy snow could cause traffic and flight delays as millions of Americans begin traveling for the Thanksgiving holiday.

FOX 17 is issuing a WEATHER READY ALERT as West Michigan faces Winter Storm Warnings and Winter Weather Advisories for up to 7" of snow and strong winds on Wednesday.

Michigan State Police recommends residents “winterize” their cars by checking car batteries, lights, brakes, and fluid levels.

Residents in Cleveland’s eastern suburbs spent Friday digging out from a 6-inch snowfall that hit on Thanksgiving, creating whiteout conditions and dangerous driving for holiday travelers.