The need for regular blood transfusions, as well as underlying processes in MDS, can result in iron overload. If left untreated, excess iron can cause widespread damage to organs throughout the body.

The aim of this study was to compare the frequencies of HFE mutations in African-American women with non-insulin-dependent diabetes mellitus (NIDDM) to that of controls and to determine whether these ...

Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with ...

Iron overload is prevalent among adults with sickle cell disease (SCD), according to a study presented at the annual meeting of the American Society of Hematology, held from Dec. 6 to 9 in Orlando, ...