Alveolar Capillary Dysplasia (ACD) is a rare, often lethal, congenital lung developmental disorder marked by an abnormality in the alignment of pulmonary veins and deficient capillary development.

This schematic shows how the small airsacs of the lung called alveoli, specifically the alveolar-capillary interface that is the major site of radiation-induced lung injury (RILI) is modeled on the ...

When babies are born with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), their skin starts to turn blue from the under-oxygenated blood in their systems. But unlike most ...

This schematic shows how the small airsacs of the lung called alveoli, specifically the alveolar-capillary interface that is the major site of radiation-induced lung injury (RILI) is modeled on the ...

Acute lung injury (ALI) is a severe inflammatory condition marked by disruption of the alveolar-capillary barrier and impaired gas exchange. Emerging evidence implicates cathepsin L as a key ...

When influenza A viruses and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infect the human body, innate immune responses in the lung act as the first line of defense against these ...

The main focus of our research is unraveling genetics of lethal lung developmental disorders. In 2009, we demonstrated that haploinsufficiency of the transcriptional factor FOXF1 gene on 16q24.1 ...

Pulmonary fibrosis is a chronic, progressive respiratory disease in which the normal barrier between alveoli and capillaries is compromised, leading to persistent injury and inflammation of the lung ...