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The cytochromes P450 (CYPs) are the main enzyme family for metabolism of therapeutic drugs. CYP3A4 is the most active drug metabolizing CYP, and it plays a prominent role in adverse drug-drug ...
Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...
May 12, 2004 — Substantial increases in trazodone hydrochloride (Desyrel) plasma concentration may occur with concurrent dosing of the cytochrome P450 3A4 (CYP3A4) inhibitors ketoconazole ...
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