BALTIMORE, July 08, 2025--BioIVT, a global research partner and biospecimen solutions provider for drug and diagnostic development, today announced the opening of its Hepatocyte Grants Program and ...

1. Khatri et. al. Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression. J Pharm Sci. September 12, 2020.

Because CYP isoenzymes metabolize a large number of structurally diverse drugs and chemicals, most of the variant genotypes of the CYP2D6, CYP2C9, CYP2C19, and CYP3A families have been identified ...

PUFA metabolites regulated by the cytochrome P450 (CYP) affect fetal development in mice causing impairments closely linked to ASD symptoms. However, it is still unclear if the same is true for ...

Sept. 16, 2003 — St. John's wort increases metabolism via the cytochrome P450 (CYP) enzyme system 3A4, according to the results of a study published in the Sept. 17 issue of The Journal of the ...

Study drug potentially weakly decreased CM metabolism in 39 cases (32%), and potentially strongly decreased CM metabolism in 28 cases (23%). CM sub was possible in 13 cases (13%). In 2 cases (1%), pts ...

Professor Matsuzaki explained the motivation behind the study, stating, “CYP metabolism forms both epoxy fatty acids (EpFAs), which have anti-inflammatory effects, and dihydroxy fatty acids, or ...

Cigarette smoke contains compounds that significantly affect drug interactions in clinical settings, primarily through the induction of cytochrome P450 (CYP) enzymes. Given the complexity of cigarette ...

Alongside the new Metabolism module, StarDrop 7.5 also includes enhanced virtual screening with Surflex eSim3D, providing a high-performance desktop experience compared to other methods requiring ...