Cytochrome P450 3A (CYP3A), which is highly expressed in the liver and in the intestine, is the most abundant cytochrome isoform in humans. CYP3A accounts for approximately 60% of the total cytochrome ...
Physicians prescribe drugs on the basis of the characteristics of the medications and on the probability that reliable and reproducible clinical effects will result. However, differences in drug ...
Oral erythromycin prolongs cardiac repolarization and is associated with case reports of torsades de pointes. Because erythromycin is extensively metabolized by cytochrome P-450 3A (CYP3A) isozymes, ...
A phase I trial of the DNA-hypomethylating agent 5-Aza-2'-Deoxycytidine in combination with carboplatin both given 4 weekly by intravenous injection in patients with advanced solid tumours This is an ...
In this issue, Suh and colleagues report on the risk of atherothrombotic events in people taking clopidogrel.1 Their main objective was to link clopidogrel efficacy to the activity of a specific CYP3A ...
A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of CHR-3996, a class 1 selective histone deacetylase inhibitor (HDACi), in patients with advanced solid tumors. Background: FAK transduces ...
JOURNAVX met the primary endpoint by demonstrating statistically significant superior reduction in pain vs placebo. 1,b JOURNAVX did not meet the first key secondary endpoint that hypothesized ...
Background: Clopidogrel is a prodrug requiring metabolism by cytochrome P450 3A (CYP3A) isoenzymes, including CYP3A5, in order to be active. It is controversial whether clopidogrel interacts with ...
Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...
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