New findings reveal how cancer manipulates immune pathways and highlight therapeutic strategies to unleash T-cells against even the most resistant tumors. Study: Cancer cells impair monocyte-mediated ...

The activation and regulation of T cells are fundamental to immune homeostasis and effective defence mechanisms. Ubiquitin ligases, such as c-Cbl and Cbl-b, serve as pivotal regulators by targeting ...

The orchestration of T cell activation is central to immune defence and self-tolerance. Recent advances have revealed that T cells integrate signals from their antigen receptors alongside a network of ...

Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be ...

St. Jude Children's Research Hospital scientists have discovered how tumors disable immune "gatekeeper" cells that alert the ...

Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

Antibody therapeutics are laboratory-made proteins designed to work like the body's natural antibodies. They are widely used ...

Led by Professor Wang Hongyan (second from the left) from Duke-NUS’ Neuroscience and Behavioural Disorders Programme, the research team, including Dr Mahekta Rajeshkumar Gujar (extreme left), PhD ...

Aging does not arrive all at once. It builds quietly across years, touching cells long before symptoms appear.