mRNA vaccines have emerged as a transformative modality for infectious disease prevention. In response to the emergence of SARS-CoV-2, large-scale in vitro transcription (IVT) of mRNA vaccines was ...
The reliance on viral vectors for the production of genetically engineered immune cells for adoptive cellular therapies remains a translational bottleneck. Here we report a method leveraging the DNA ...
Linear DNA templates let researchers bypass the additional cloning, purification, linearization, or amplification steps often associated with plasmid-based templates. mRNA is commonly transcribed from ...
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