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Single-cell atlas reveals hidden patterns of differentiation in acute myeloid leukemia

Analysis showed that primitive stem-like differentiation patterns were more common in adult AML compared to pediatric AML, while monocytic differentiation patterns were more frequent among pediatric ...
Nature

Waddington’s landscape, and the different shades of differentiation

I've flippantly used Mystique as my metaphor for explaining stem cells. I've also been promising some serious stem cell biology that I've found hard to adapt to the Mystique angle, mainly because of ...
Nature

A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis

The K562 cell line serves as a model to study the molecular mechanisms associated with leukemia differentiation. We show here that cotreatment of K562 cells with PMA and low doses of SB202190 (SB), an ...