Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen. Patients may ...

Examination of Japanese cases of gynecological cancer offers a better understanding of the profile of a rare ovarian tumor and could change treatment guidelines. Ovarian granulosa cell tumors are a ...

This photo shows a mouse obtained from gPSC4-derived oocytes by IVM and IVF. The mouse is now about one year old. The gPSC4- mice have reproductive ability and produced 13 and 7 pups, respectively, ...

Ovarian follicles are the basic functional unit of the ovary and consist of an oocyte, the immature egg, which is surrounded by granulosa cells. Besides being crucial to the development of follicles, ...

The study found that FSH controls follicular fluid (FF) glutamine levels to determine ovulation. In mice, ovulation starts from FF-exposing granulosa cell (GC) apoptosis. FF glutamine, which decreases ...

This study is led by Prof. Yang Yu (Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital). Age-related female infertility and increase of the ...

Communication between oocytes and granulosa cells is essential for oocyte formation, dormancy, reawakening, and maturation. Researchers at University of Tsukuba have demonstrated that a protein ...

Forkhead box protein L2 (FOXL2) is a protein involved in ovary development and maintenance, among other functions. Mutations in its gene are involved in ovarian failure and granulosa cell tumors, ...