Nature

Long-Lasting Effects of a PEGylated Mutant Cocaine Esterase (CocE) on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rats

Male Sprague-Dawley rats (325–350 g) were obtained from Harlan (Indianapolis, IN) and maintained in a temperature and humidity controlled environment, on a 12-h dark/light cycle with lights on at 0700 ...
Animal Welfare Institute

Chesler, K. C., Motz, C. T., Bales, K. L. et al. 2022. Voluntary oral dosing for precise experimental compound delivery in adult rats. Laboratory Animals 56(2), 147-156.

Preclinical drug studies routinely administer experimental compounds to animal models with the goal of minimizing potential adverse events from the procedure. In this study, we assessed the ability to ...
JSTOR Daily

Effects of 3,3′-Iminodipropionitrile (IDPN) on Behavior and LDH Activity in Rats

This is a preview. Log in through your library . Abstract 3,3′-Iminodipropionitrile (IDPN) is a synthetic neurotoxicant. The purpose of this study was to observe the effects of IDPN on rat behavior ...
JSTOR Daily

Low-Dose Pharmacokinetics and Oral Bioavailability of Dichloroacetate in Naive and GSTζ-Depleted Rats

This is a preview. Log in through your library . Abstract We studied the pharmacokinetics of dichloroacetate (DCA) in naive rats and rats depleted of glutathione S-transferase-zeta (GSTζ), at doses ...