Genome-wide analyses have revealed a great diversity of transcription initiation complexes that can bind to promoters transcribed by RNA polymerase II (Pol II) and, correspondingly, variation in core ...

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...

Transcription initiation and elongation of HIV-1 are critical processes regulating viral latency and activation. Despite these two processes playing essential roles in HIV-1 gene expression, how they ...

These sequences are extremely prone to mutations and rank among the most functionally important regions in the entire human ...

Rosalind Franklin, James Watson and Francis Crick discovered the structure of DNA -- that molecular blueprint for life -- over 70 years ago. Today, scientists are still uncovering new ways to read it.

Researchers have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the ...

Transcription is the first step of gene expression, where a DNA sequence is copied into messenger RNA. In eukaryotes, transcription initiation starts with the assembly of the transcription ...

A newly discovered promoter element "start" points to a shared regulatory syntax for controlling transcription initiation in ...

All three RNAPs have catalytic cores consisting of 10 subunits. Five of these are core subunits which form crab claw shapes with DNA at their centres, channels for RNA products and NTP substrates as ...

There are a total of 5 multi-subunit complexes in the inner membrane of the mitochondria, all of which are involved in the process of oxidative phosphorylation that precedes ATP production. Of these, ...