Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.

Different interferons can be obtained from the same animal species depending on the cells and (or) the inducers used. Interferons of type I and type II differ not only antigenically but also in ...

A significant body of data implicates the type I interferon (IFN) pathway in the pathogenesis of autoimmune rheumatic diseases. In these disorders, a self-reinforcing cycle of IFN production can ...

In findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help ...

In a recent study posted to the bioRxiv* preprint server, researchers assessed the roles of the interferon (IFN) regulatory factors (IRFs): IRF1, IRF3, and IRF7 in infections by human coronaviruses ...

Our bodies create vitamin D when ultraviolet rays in sunlight convert a protein called 7-dehydrocholesterol in the skin into ...

Alzheimer's disease (AD), the most common type of dementia, progressively impairs memory, concentration and the ability to learn new things and accomplish everyday activities. Although scientists do ...

Vitamin D3 is more effective than D2 in enhancing vitamin D in our body. But vitamin D2 fortified foods may lower natural D3 ...

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus ...