Finally, further catalytic enamine activation initiates an intramolecular aldol condensation to close the six-membered ring.

The combination of these two fragments was achieved using an intramolecular aldol reaction. The diene produced underwent ring-closing metathesis to form an 11-membered ring — again, a ...

The fatty acid ester was nonenzymatically converted to a butenolide phosphate by intramolecular aldol condensation. The butenolide phosphate was then reduced by BprA that was encoded just downstream ...