MEK1/2 have crucial roles in mediating cellular signals transduced from RAS–RAF, an oncogenic pathway implicated in numerous types of tumour, and are therefore attractive targets for cancer therapy ...

Metastatic melanoma is a deadly cancer for which conventional chemotherapy provides little benefit. However, newer therapies involving a pathway called the mitogen-activated protein kinase (MAPK) ...

Radiosurgery as primary treatment of metastatic tumors of the spine: Quality of life and adjuvant surgical approach after Cyberknife. Background: AZD6244 is a second generation MEK inhibitor that ...

Phase 1/2 study of pembrolizumab (pembro) in children with advanced melanoma or a PD-L1-positive (PD-L1+) advanced, relapsed, or refractory solid tumor or lymphoma (KEYNOTE-051). This is an ASCO ...

This 72-year-old man had had hairy-cell leukemia since he was 50 years of age. After an initial splenectomy at that time, he remained in good health for 14 years. A third relapse 21 years after the ...