The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region ...

Heat shock proteins (HSPs) and molecular chaperones are fundamental to cellular proteostasis, ensuring proteins achieve and maintain their functional conformation while preventing misfolding and ...

A new PNAS study unveils a hidden vulnerability of prostate cancer: the protein-disulfide isomerases , which stabilize (AR) and sustain tumor survival. Inhibition of these enzymes destabilizes AR, ...

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The National Institutes of Health has recently granted $740K to the University of North Florida to investigate a hallmark of ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

Award will allow Priya R. Banerjee to continue research on biomolecular condensates and their role in disease.

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia, with symptoms appearing after age 65. Since carriers of clusterin risk alleles have an increased likelihood of developing ...

Heat shock proteins (HSPs) and molecular chaperones are integral to the maintenance of cellular proteostasis, ensuring that proteins attain and retain their correct conformation even under adverse ...