Peptide amidation is a ubiquitous posttranslational modification of bioactive peptides. Peptidylglycine α-hydroxylating monooxygenase (PHM; EC 1.14.17.3), the enzymne that catalyzes the first step of ...
Cells use flavin monooxygenases to break down foreign molecules by adding oxygen atoms to them. Biochemists have long assumed that the enzymes use a particular cofactor adduct to add the oxygen. A new ...
Researchers from Bochum and Leipzig have successfully used a soil bacterium to specifically produce prodrugs. The key to this step was a detailed understanding of the metabolization of indole. The ...
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