Skeletal muscle is the type of muscle that controls movement. Problems with these muscles can be minor, life-threatening, or ongoing problems that make it hard to perform basic daily activities.
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
This genetic model suggests otherwise, indicating that coupled gating or other mechanical interactions, rather than CICR, drive activation of uncoupled RyR1 channels. Interestingly, the researchers ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
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