POPLAR BLUFF, Mo. (WSIL) -- One person is dead after a vehicle vs pedestrian crash in southeast Missouri on Monday. The Missouri State Highway Patrol reported the crash happened on January 26, at ...

Poplar Bluff High School principal Valerie Ivy has been named Missouri's 2026 High School Principal of the Year, a first-ever statewide honor for the district.

A Missouri man died after a pickup backed into him, causing him to hit another vehicle.

Former State Representative Jeff Shawan today announced that he is running for the Missouri House of Representatives in the 152nd District, offering Butler County voters a familiar and trusted ...

A potentially historic winter storm is poised to strike our region late Friday, threatening to paralyze the area with more ...

A man was hospitalized early Saturday morning after his pickup truck ran off the road and overturned.

After multi-agency raids in Poplar Bluff netted drugs and weapons, suspected double-murderer Michael Antonio McNair Jr.

Most Saint Francis clinics at Poplar Bluff's Coppertop have closed, with only urgent care, lab, imaging and fourth-floor ...

POPLAR BLUFF, Mo. (KFVS) - John’s Pharmacy announced it will take over ownership and operation of Saint Francis Healthcare System’s retail pharmacy in Poplar Bluff. They say they will take over on ...

POPLAR BLUFF, Mo. (KFVS) - Country music will face off against rock music during the Clash at the Coliseum concert happening later this month. The concert, presented by Pop’s Events, will take place ...

WAYNESVILLE -- The Capital City Cavaliers erased a 20-point deficit Friday night, but the Poplar Bluff Mules regrouped with a strong fourth quarter to finish out a 63-54 victory in the Route 66 ...