The specific activity of pyruvate carboxylase [pyruvate:carbon-dioxide ligase (ADP-forming); EC 6.4.1.1] in 3T3-L1 cells increases approximately 20-fold when these cells differentiate to an ...
(WTHR) — Allison and Ben Gauvin have lost two children to a rare mitochondrial disease, called pyruvate carboxylase deficiency, believe it's made them better parents to their other two children, who ...
HEREDITARY spherocytosis with its associated congenital hemolytic anemia is generally easily recognized and satisfactorily treated with splenectomy. A rarer group of congenital hemolytic anemias, ...
Phosphoenolpyruvate carboxylase (PEPC; EC4.1.1.31) plays a key role during C₄ photosynthesis. The enzyme is activated by metabolites such as glucose-6-phosphate and inhibited by malate. This ...
Four mitochondrial metabolic liver enzymes require bicarbonate, which is provided by the carbonic anhydrase isoforms VA (CAVA) and VB (CAVB). Defective hepatic bicarbonate production leads to a unique ...
THE hemolytic anemia associated with erythrocyte pyruvate kinase deficiency is of variable severity 1–17 and probably of variable cause. In some cases severe aberrations of erythrocyte shape ...
Credit: Shutterstock. Mitapivat is a first-in-class, oral, selective small molecule allosteric activator of pyruvate kinase-R enzymes. The Food and Drug Administration (FDA) has accepted for Priority ...
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