When we learn a new motor skill—whether mastering a piano passage or refining balance while walking—the brain must reorganize the circuits that control movement. For decades, this process of synaptic ...

Astrocytes use the MEGF10 receptor to prune synapses in the striatum, a process essential for dopamine-driven motor learning.

Behavioral assays linked these molecular disturbances to functional outcomes. Exposed fish displayed increased locomotor activity, heightened anxiety-like behavior, and altered learning performance, ...

The formation of excitatory and inhibitory synapses between neurons during early development gives rise to the neuronal networks that enable sensory and cognitive functions in humans. Inhibitory ...

Researchers from Kyushu University discovered a previously unrecognized synaptic "hotspot" that forms during adolescence, challenging the long-held view that adolescent brain development was dominated ...

Representative cryo-electron microscopy image: a coloured image of the 3D structure of gephyrin, which was calculated from the data. A team of scientists from the University of Cologne’s Institute of ...

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

The storage and retrieval of information encoded in the nervous system are often accompanied by morphological changes in the participating neurons. During brain development, neurite elongation and ...

The ability to regrow lost synapses can be life changing; for Derek Small, cofounder and CEO of the start-up Syndeio Biosciences, it holds personal relevance. Around a decade ago, Small watched his ...