Misfolded α-synuclein is heavily implicated in the pathogenesis of Parkinson's disease. In its native state, α-synuclein is widely believed to be a 14-kDa unfolded monomer. Selkoe and colleagues now ...

A review discusses what immunotherapies are currently being evaluated to target α-synuclein, an abnormal protein suggested to have a central role in the pathogenesis of PD. Parkinson disease (PD) is ...

New York, USA, Feb. 13, 2025 (GLOBE NEWSWIRE) -- Alpha-Synuclein Inhibitors Clinical Trial Pipeline as Novel and Extensive 22+ Therapies Likely to Enter in the Domain | DelveInsight Alpha-synuclein ...

By mapping protein interactions in biofluids, researchers gained new insights into alpha-synuclein’s role in Parkinson’s ...

Misfolding and aggregation of normally soluble proteins are common pathological features of many neurodegenerative diseases, including Alzheimer's, Parkinson's, Creutzfeldt-Jacob and Huntington's ...

The so-called isolated REM-sleep behavior disorder is a condition that can provide an indication of Parkinson's disease well in advance. A research team headed by Professor Dr Erdem Gültekin Tamgüney ...

A toxic protein forms dynamic pores in the membranes of brain cells—and that may be the key to understanding how Parkinson's disease develops. This is the conclusion of a new study from Aarhus ...

[Editor’s note posted 7 March 2025: The Larson et al paper covered in this news story has been retracted.] Alzheimer’s disease is usually thought of as a disorder of two proteins, Aβ and tau, but ...

Amsterdam, NL, November 13, 2019 - Aggregates of the protein alpha-synuclein arising in the gut may play a key role in the development of Parkinson's disease (PD). Investigators are testing the ...

Key proteins implicated in neurodegenerative diseases are alpha synuclein and tau. Tau aggregation into neurofibrillary tangles, along with amyloid-beta aggregation into plaques, is a hallmark of ...

A new double-transgenic mouse may provide a good model for Lewy-body diseases and offer insight into mechanisms that underlie Alzheimer's and Parkinson's disease. Eliezer Masliah and colleagues at ...