For decades, treating major depression has involved a frustrating cycle of trial and error, with patients cycling through medications and therapies while clinicians rely on symptoms and intuition more ...

A new brain-imaging study has revealed how ketamine produces its fast antidepressant effects in people with treatment-resistant depression. Researchers tracked changes in a critical brain receptor ...

A new study published in npj Mental Health Research reports that a specific brain-network signal may reliably predict whether ...

Deep brain stimulation – implants in the brain that act as a kind of 'pacemaker' – has led to clinical improvements in half of the participants with treatment-resistant severe depression in an 'open ...

Early in the pain process, newly generated neurons in the dentate gyrus showed increased activity – suggesting the brain initially mounts a protective response to persistent pain. Over time, however, ...