DNA damage, caused by radiation and a variety of chemical agents, can lead to mutations, genomic instability, cancer and cell death. Genetic studies in the yeast Saccharomyces cerevisiae have revealed ...

Cdc25 activates maturation promoting factor (MPF) and promotes mitosis by removing the inhibitory phosphate from the Tyr-15 of Cdc2 in human cells. In this study, we searched the interacting protein(s ...

Aria becomes PCNA’s first vice president of Strategy and Digital Business · GlobeNewswire Inc. Atlanta, Feb. 12, 2024 (GLOBE NEWSWIRE) -- Zabih Aria has been named Vice President of Strategy and ...

“This finding implicates that targeting PCNA/AR interaction could be an innovative strategy for therapy against CRPC.” In this study, authors Shan Lu and Zhongyun Dong from the University of ...

To trip up fast-proliferating cancer cells, try throwing a wrench in their proliferation machinery, the aptly named proliferating cell nuclear antigen (PCNA). Wielding a new kind of wrench, a ...

CLEVELAND - October 3, 2017 - Proforma’s Owner Advisory Council (OAC), member owners elected each year to represent their geographical regions, recently held its annual planning meeting at the ...

Cancer is essentially just cells that have gone rogue and are dividing unchecked, and now Australian researchers have designed a new molecule that may put a stop to that. It targets a protein called ...

Scientists reported a novel molecular mechanism for the regulation of PCNA cycling during DNA replication. They proved that ATAD5-RLC opens PCNA ring to be removed from DNA as a bona-fide PCNA ...