Cubs rookie Cade Horton has been inconsistent, but he has fanned 4+ batters in five of his last seven starts. He'll face a White Sox lineup that is 29th in the majors in OPS (.660) and 24th in strikeout rate (23.2%).

SportsLine's proven model has simulated the Chicago White Sox vs. Chicago Cubs 10,000 times and released its MLB best bets for Illinois sportsbooks

The Chicago Cubs (60-42) visit the South Side of Chicago to face the Chicago White Sox (37-66) Friday in the first game of a 3-game interleague series. First pitch from Rate Field is at 7:40 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.