Nature

Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance

Rodent ClC-K1 and ClC-K2, and their respective human orthologs ClCKA and ClCKB, are chloride channels specific to the kidney (and inner ear); Barttin is their functionally important subunit. ClC-K1 is ...
Nature

Replacement of renal function in uremic animals with a tissue-engineered kidney

Current renal substitution therapy with hemodialysis or hemofiltration has been the only successful long-term ex vivo organ substitution therapy to date. Although this approach is life sustaining, it ...
IEEE

Low-Rank Tensor Function Representation for Multi-Dimensional Data Recovery

Abstract: Since higher-order tensors are naturally suitable for representing multi-dimensional data in real-world, e.g., color images and videos, low-rank tensor representation has become one of the ...
PNAS

Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned

Contributed by William G. Kaelin, Jr.; received May 3, 2024; accepted September 3, 2024; reviewed by M. Celeste Simon and Arul M. Chinnaiyan We designed CRISPR sgRNAs ...