Finding a safe combination is a classic Resident Evil puzzle, and Requiem has a handful for you to pop open across its key ...
The Basement safe can be found in the room above Processing on the west side of the Care Center's Basement. Open the door on the west side of the Furnace with a joint plug to enter a room just north ...
If you're trying to obtain the No Safe is Safe trophy, you'll need to channel your inner Catwoman and open every safe in Resident Evil Requiem.