The same storm and cold front is also expected to bring thunderstorms and a chance of heavy rain on Saturday from southern Missouri down to Louisiana and Texas.

The National Weather Service of Indianapolis has declared a winter storm watch for areas above I-70 from Friday night into Sunday afternoon. NWS Indianapolis predicts the region will see total snow accumulations between 3 and 6 inches possible.

A mess of snow changing to rain or mix is possible Saturday across Indiana as our next storm arrives. Those who don't see much rain could get 4+ inches of snow.

A pileup involving about 45 cars occurred in Indiana on Interstate-40 on Saturday, Nov. 29, at about 10 a.m. local time. Authorities said no injuries have been reported, but they are urging residents to stay inside amid the winter weather conditions.

Around 20 to 30 vehicles were involved in a massive pileup on an Indiana interstate as snow pummeled the region, authorities said.

Photographs from state traffic cameras show widespread wreckage, with many vehicles scattered across and off the highway.

Snow is falling across Chicagoland on Saturday morning. Cold air settling into the central and eastern US will set the stage for multiple storms next week, bringing snow farther to the south and east with travel disruptions from the Plains to New England.