For some people, diet, and exercise are not enough to lose weight and keep it off. This is where weight loss medication, including weight loss pills, comes in. When combined with diet and exercise, the best weight loss pills can help you lose weight—and keep it off—by: Suppressing your appetite (decreasing your desire to eat).

While plenty of people rave about the weight loss results you can get from drugs like Ozempic, there’s also been a ton of chatter over the fact that these meds are really expensive. These drugs have also been in and out of shortage, making it tough to get your hands on Ozempic and similar medications—if you can afford it.

Novo Nordisk (NVO), the maker of blockbuster weight-loss and diabetes drugs Wegovy and Ozempic, has entered an agreement with Denmark-based Ascendis Pharma (ASND) to leverage the latter’s advanced drug delivery technology.