Brain cytochrome P450 (CYP) enzymes represent a specialised set of metabolic proteins that, while less abundant than their hepatic counterparts, play an increasingly acknowledged role in the local ...

Inhibition of the soluble epoxide hydrolase (sEH) enzyme diminishes degradation of epoxyeicosatrienoic acids, which can enhance their beneficial cardiovascular actions. Here, Imig and Hammock ...

Cigarette smoke contains compounds that significantly affect drug interactions in clinical settings, primarily through the induction of cytochrome P450 (CYP) enzymes. Given the complexity of cigarette ...

Enzymes are vital to metabolism and drive countless biological processes in humans, plants, and industry. Yet, when ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the ...

"BioIVT continues to pioneer critical research, including recent findings around the evaluation of CYP- and non-CYP enzyme-based metabolism of drug candidates in drug development and drug-drug ...

Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid ...

A new drug was shown to significantly reduce tumor growth in lab studies by up to 77% for melanoma and colorectal cancers.

Mergers, acquisitions, and collaborative commercialization strategies are likely to intensify as stakeholders seek to capture growth across both developed and emerging regions. The CYP17A1 inhibitors ...

The CYP17A1 inhibitors market is projected to attain USD 1,350 million by 2025, expanding at a robust CAGR of 8.5% between 2025 and 2032, supported by strong pipeline activity, expanded ...

CYP3A4 inhibition elevates serum DHE levels, raising the risk of vasospasm leading to cerebral ischemia or ischemia of the extremities.

Prostate cancer is one of the most common malignancies in men globally. Hormonal therapies targeting the androgen–androgen receptor axis have significantly delayed disease progression. However ...