Professor Matsuzaki explained the motivation behind the study, stating, “CYP metabolism forms both epoxy fatty acids (EpFAs), which have anti-inflammatory effects, and dihydroxy fatty acids, or ...

BALTIMORE, July 08, 2025--BioIVT, a global research partner and biospecimen solutions provider for drug and diagnostic development, today announced the opening of its Hepatocyte Grants Program and ...

Cigarette smoke contains compounds that significantly affect drug interactions in clinical settings, primarily through the induction of cytochrome P450 (CYP) enzymes. Given the complexity of cigarette ...

1. Khatri et. al. Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression. J Pharm Sci. September 12, 2020.

To further complicate matters, CYP metabolism can either decrease or increase the blood levels of the active opioid, depending on the drug in question. Some opioids have no analgesic properties until ...

Technical Terms Cytochrome P450 (CYP) enzymes: A diverse family of enzymes that catalyse the oxidation of various compounds, influencing both drug and endogenous molecule metabolism.

Reference White CM. Inflammation suppresses patients’ ability to metabolize cytochrome P450 substrate drugs. Ann Pharmacother. Published online September 30, 2021. doi.org/10.1177/10600280211047864.

Sept. 16, 2003 — St. John's wort increases metabolism via the cytochrome P450 (CYP) enzyme system 3A4, according to the results of a study published in the Sept. 17 issue of The Journal of the ...

Because CYP isoenzymes metabolize a large number of structurally diverse drugs and chemicals, most of the variant genotypes of the CYP2D6, CYP2C9, CYP2C19, and CYP3A families have been identified ...

Professor Matsuzaki explained the motivation behind the study, stating, “CYP metabolism forms both epoxy fatty acids (EpFAs), which have anti-inflammatory effects, and dihydroxy fatty acids, or ...