The Lancet11h
Sodium–glucose co-transporter inhibitors—who would have guessed?
Prediction is very difficult, especially about the future”; whether it is the Nobel laureate Niels Bohr or others who have ...
Healio1d
VIDEO: PI3K inhibitors, combinations maintain quality-of-life in metastatic breast cancer
In this video, Aruna Padmanabhan, MD, discusses therapy combinations for the treatment of PIK3CA-mutated metastatic breast cancer.
Frontiers2d
Exploring Small Molecule Inhibitors in Cancer, Inflammation, and Autoimmune Disorders
Given the success of the previous Research Topic 'Exploring Small Molecule Inhibitors in Cardiovascular and Cerebrovascular Diseases', we are pleased to ...
Medscape26d
Effects of Genetic Polymorphisms on the Pharmacokinetics of Calcineurin Inhibitors
Using genetic markers to adjust initial doses of cyclosporine or tacrolimus may prove difficult, considering the variety of polymorphisms known to affect CYP3A4, CYP3A5, and MDR1. The current ...
Medscape26d
Update on the Pharmacogenomics of Proton Pump Inhibitors
These tests detect variations in the genes coding for enzymes involved in drug metabolism, for example CYP2C19 ... among the different proton pump inhibitors (PPIs), which might influence their ...
C&EN29d
Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease
Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany German Center for Infection Research (DZIF), Hannover-Braunschweig Site, ...