Noting that ketone bodies are easy to manipulate experimentally and therapeutically, Newman adds, "This might be a powerful avenue to assist with global clearing of damaged proteins.

Senior author John Newman, MD, Ph.D., an assistant professor at the Buck, says many theorized that the ketone body-based improvements were caused by increased energy to the brain or a reduction in ...

Ketone bodies interact with damaged and misfolded proteins directly, making them insoluble so they can be pulled from the cell and recycled." John Newman, Assistant Professor, Buck Institute for ...

Ketone bodies are not just about energy. These metabolites are powerful signaling molecules that have profound effects on the proteome and protein quality control in the brain.