Skenes fell to 0-4 in five career starts against the Cardinals after a 2-1 loss Tuesday night. It's the most starts by a Pirates pitcher to begin a career against St. Louis without a win since JT Brubaker went 0-6 in eight starts in 2021 and 2022.

Two RBIs from Alec Burleson, seven innings from starter Matthew Liberatore and a save in his first opportunity by Gordon Graceffo helped the Cardinals beat the Pirates 2-1 on Tuesday.

Despite a strong start from Skenes (3-4), the Pittsburgh Pirates were defeated 2-1 at Busch Stadium on Tuesday night for their sixth-straight loss.