The EMBO Journal

Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Selective autophagy cargos are recruited to ...
The EMBO Journal

High‐throughput metabolomics predicts drug–target relationships for eukaryotic proteins

Chemical probes are important tools for understanding biological systems. However, because of the huge combinatorial space of targets and potential compounds, traditional chemical screens cannot be ...
The EMBO Journal

Deregulations of miR‐1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Increased cardiac expression of Multiplexin ...
The EMBO Journal

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Dynamin 1 mediates fission of endocytic ...
The EMBO Journal

Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Conditional mutagenesis in mice identifies a ...
The EMBO Journal

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The ...
The EMBO Journal

PABP prevents the untimely decay of select mRNA populations in human cells

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Gene expression is tightly regulated at the ...
The EMBO Journal

TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Telomerase plays a pivotal role in ...
The EMBO Journal

Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cellular metabolism must adapt to changing ...
The EMBO Journal

Role and mechanism of PVN–sympathetic–adipose circuit in depression and insulin resistance induced by chronic stress

Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue ...
The EMBO Journal

Genetically modified macrophages accelerate myelin repair

Preventing neurodegeneration‐associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this ...
The EMBO Journal

A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The accumulation of misfolded and aggregated ...