The season debut of Christian McCaffrey helped make the San Francisco 49ers offense look more like it did a year ago than it ...

The Seattle Seahawks will visit the San Francisco 49ers in a key game in the NFC West race with both teams trying to catch ...

Tampa Bay Buccaneers Tackle Luke Goedeke was mic'd up for Week 10's Salute to Service game against the San Francisco 49ers. Hear from Luke in this week's edition of Mic'd Up.

The San Francisco 49ers earned a hard-fought victory on Sunday against the Tampa Bay Buccaneers, securing back-to-back wins ...

Deebo Samuel revealed why San Francisco quarterback Brock Purdy was upset after Sunday's win over the Tampa Bay Buccaneers.

The San Francisco 49ers have another important division game on Sunday, but they may have to play without two of their biggest stars.

Having put their best foot forward dealing with a host of injuries, namely to Mike Evans and Chris Godwin, but others in ...

Mitch Wishnowsky (back) missed a second practice this week, and newly signed punter Pat O’Donnell was on the field working ...

Asked how it must have felt for Moody to go from the 49ers' biggest loser to the hero of the show, Kyle Shanahan broke down ...

Star pass-catcher George Kittle and the San Francisco 49ers face the Seattle Seahawks on Sunday at 4:05 p.m. ET, at Levi’s ...

This did not escape two of Mayfield's big media fans, Fox sideline reporter Erin Andrews and studio host Charissa Thompson.

Trent Williams missed his second practice in a row on Thursday with an ankle injury. He also sat on Wednesday, but his absence flew under the radar because ...