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For over 60 years, we thought metformin worked mainly through the liver and gut. But new research suggests the brain may play a major role too. This study identified a specific brain pathway (Rap1 in the hypothalamus) that appears critical to metformin’s glucose-lowering effects, potentially reshaping how we understand one of the world’s most prescribed diabetes medications. Source: Sci. Adv. 2025;11:eadu3700
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Sometimes the shift starts before the argument does. A delayed reply feels like rejection. Your mind starts looking for proof they’re pulling away. You might ask for reassurance, go quiet, or feel an urge to push them away first. If you live with BPD, these can be signs that fear is taking over, not proof that the other person has stopped caring. Try pausing and asking yourself: “What happened, and what am I afraid it means?” Which sign do you notice first? 🦋🤎 #BPD #BorderlinePersonalityDisord
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How unlikely is it that I’ll get norovirus? Spoiler: You can’t calculate that and everytime you try, your brain continues to learn that it’s super important — and emetophobia continues to rule. Accept the constraint: We can’t know. Acceptance = path to recovery #emetophobiaawareness #emetophobia #throwup #mentalhealth #stomachbug
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