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GABA!!! Two big distinctions here— positive allosteric modulators (benzos) vs direct agonists (anesthetics like propofol or alfaxalone). Disinhibitions occurs because downstream neurons are not receiving inhibitory signals anymore (because that presynaptic neuron is inhibited by our drug while normally it releases GABA to calm downstream neurons). neuropharm is so juicy. #fyp #gaba #vetmed
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